계명대학교 의학도서관 Repository

흰쥐에서 streptozotocin에 의해 유도된 당뇨병에 대한 운동과 melatonin의 효과

Metadata Downloads
Author(s)
최혜정장은주김유현김기진문교철Hye-Jung ChoiEun-Ju ChangYu-Hyun KimKi-Jin KimKyo-Cheol Mun
Keimyung Author(s)
Mun, Kyo Cheol
Department
Dept. of Biochemistry (생화학)
Journal Title
대한스포츠의학회지
Issued Date
2005
Volume
23
Issue
2
Abstract
The effects of melatonin and exercise on diabetes mellitus induced by streptozotocin in male Sprague-Dawley rats were studied. Diabetes was induced by the intraperitoneal injection of 65 mg of streptozotocin per kg of body weight. To know the effect of melatonin, a dose of 10 mg of melatonin per kg of body weight was administered intraperitoneally. And to know the effect of exercise, rats were performed exercise by a treadmill running at the speed of 10 m/minute, 8% of slope, for 60 minutes in a day for 1 week. The parameters including the levels of blood glucose, hemoglobin A1C, and malondialdehyde analysed to evaluate diabetic state and the degree of lipid peroxidation by oxygen free radicals. The injection of streptozotocin caused significant increases in the levels of blood glucose, hemoglobin A1C and malondialdehyde. Melatonin and exercise reduced significantly the levels of blood glucose, hemoglobin A1C and malondialdehyde which were increased by streptozotocin injection. When the effect of melatonin and exercise in the diabetic rats was compared the exercise was more effective for normalizing the parameters which were changed by streptozotocin injection than melatonin. These results may suggest that melatonin and exercise are effective the oxidative damage in the diabetes induced by streptozotocin. Exercise is more protective for diabetes mellitus than melatonin.
Alternative Title
Effects of Exercise and Melatonin on the Diabetes Mellitus Induced by Streptozotocin in Rats
Keimyung Author(s)(Kor)
문교철
Publisher
School of Medicine
Citation
최혜정 et al. (2005). 흰쥐에서 streptozotocin에 의해 유도된 당뇨병에 대한 운동과 melatonin의 효과. 대한스포츠의학회지, 23(2), 145–151.
Type
Article
ISSN
1226-3729
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39253
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.