Hypereosinophilic syndrome is a rare disorder that can cause ischemic stroke. We report two patients with cerebral infarction due to hypereosinophilic syndrome. Brain MRI of each patient revealed different lesion patterns of cerebral
infarcts, which included multiple border-zone infarcts and a small perforating-artery infarct. The mechanism underlying the small infarct in one of the patients was presumed to be vascular endothelial toxicity by eosinophilic cells and local thrombus formation, and the distinguishing lesion pattern of this patient has not been reported previously.