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Rapid, objective and non-invasive diagnosis of sudomotor dysfunction in patients with lower extremity dysesthesia: A cross-sectional study

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Author(s)
Choong Sik ChaeGeun Young ParkYong-Min ChoiSangeun JungSungjun KimDonggyun SohnSun Im
Keimyung Author(s)
Choi, Yong Min
Department
Dept. of Rehabilitation Medicine (재활의학)
Journal Title
Annals of Rehabilitation Medicine
Issued Date
2017
Volume
41
Issue
6
Keyword
Diabetes mellitusGalvanic skin responsePolyneuropathiesRadiculopathySmall fiber neuropathy
Abstract
Objective:

To determine whether patients with lumbosacral (LS) radiculopathy and peripheral polyneuropathy (PPNP) exhibit sudomotor abnormalities and whether SUDOSCAN (Impeto Medical, Paris, France) can complement nerve conduction study (NCS) and electromyography (EMG).

Methods:

Outpatients with lower extremity dysesthesia underwent electrophysiologic studies and SUDOSCAN. They were classified as normal (group A), LS radiculopathy (group B), or PPNP (group C). Pain severity was measured by the Michigan Neuropathy Screening Instrument (MNSI) and visual analogue scale (VAS). Demographic features, electrochemical skin conductance (ESC) values on hands and feet, and SUDOSCAN-risk scores were analyzed.

Results:

There were no statistical differences in MNSI and VAS among the three groups. Feet-ESC and hands-ESC values in group C were lower than group A and B. SUDOSCAN-risk score in group B and C was higher than group A. With a cut-off at 48 microSiemens of feet-ESC, PPNP was detected with 57.1% sensitivity and 94.2% specificity (area under the curve [AUC]=0.780; 95% confidence interval [CI], 0646-0.915). With a SUDOSCAN-risk score cut-off at 29%, NCS and EMG abnormalities related to LS radiculopathy and PPNP were detected with 64.1% sensitivity and 84.2% specificity (AUC=0.750; 95% CI, 0.674-0.886).

Conclusion:

SUDOSCAN can discriminate outpatients with abnormal electrophysiological findings and sudomotor dysfunction. This technology may be a complementary tool to NCS and EMG in outpatients with lower extremity dysesthesia.
Keimyung Author(s)(Kor)
최용민
Publisher
School of Medicine (의과대학)
Citation
Choong Sik Chae et al. (2017). Rapid, objective and non-invasive diagnosis of sudomotor dysfunction in patients with lower extremity dysesthesia: A cross-sectional study. Annals of Rehabilitation Medicine, 41(6), 1028–1038. doi: 10.5535/arm.2017.41.6.1028
Type
Article
ISSN
2234-0645
DOI
10.5535/arm.2017.41.6.1028
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41431
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학)
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