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Plasma sphingomyelins increase in prediabetic Korean men with abdominal obesity

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Affiliated Author(s)
임승순정인성송대규
Alternative Author(s)
Im, Seung SoonChung, In SungSong, Dae Kyu
Journal Title
PLoS One
ISSN
1932-6203
Issued Date
2019
Abstract
Abdominal or visceral obesity is a well-known risk factor for metabolic diseases. However, whether abdominal obesity significantly affects plasma lipid profile during the development of type 2 diabetes has not been fully elucidated. We investigated the differences in plasma lipid concentrations in 63 participants categorized into six groups (middle-aged Korean men); Normal, Pre-diabetes (pre-DM), and Diabetes mellitus (DM) with or without abdominal obesity (AO or lean). The lipidomic profiles were determined by using liquid chromatography- tandem mass spectrometry (LC-MS/MS). Sphingomyelin (SM) levels in plasma were significantly higher in the pre-DM with AO than in pre-DM with lean (p = 0.021). SM concentrations correlated positively with waist-to-hip ratio (WHR) (r = 0.256, p = 0.044), cholesteryl ester (CE) (r = 0.483, p < 0.0001), ceramide (r = 0.489, p < 0.0001) and plasmanyl phosphatidylcholine (PC) (r = 0.446, p < 0.0001). The present study found that pre-diabetic patients with AO were characterized by increased plasma concentrations of SM. Plasma SM levels in individuals with AO may be an early prognostic biomarker to better predict the progression toward type 2 diabetes and metabolic syndrome.
Department
Dept. of Physiology (생리학)
Dept. of Preventive Medicine (예방의학)
Publisher
School of Medicine (의과대학)
Citation
Seung-Soon Im et al. (2019). Plasma sphingomyelins increase in prediabetic Korean men with abdominal obesity. PLoS One, 14(3). doi: 10.1371/journal.pone.0213285
Type
Article
ISSN
1932-6203
DOI
10.1371/journal.pone.0213285
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41947
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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