Clinicopathological and Prognostic Characteristics of RAD51 in Colorectal Cancer

Authors
Jae-Ho LeeAn-Na BaeSoo-Jung Jung
Department
Dept. of Anatomy (해부학)
Issue Date
2020
Citation
Medicina (Kaunas), Vol.56(2) : 48-48, 2020
ISSN
1010-660X
Abstract
Background and Objectives: RAD51 plays an essential role in DNA repair via homologous recombination. RAD51 facilitates strand transfer between interrupted sequences and their undamaged homologies. Therefore, we studied the RAD51 mRNA expression levels in colorectal cancer (CRC), and evaluated the clinicopathological and prognostic significance of RAD51. Materials and Methods: The RAD51 expression was examined in 48 CRCs and paired adjacent non-tumor tissues. We further evaluated the survival to determine the prognostic value of RAD51 in our CRC and The Cancer Genome Atlas (TCGA) data. Results: We confirmed that the RAD51 expression in tumor tissues, compared with that of paired non-tumor tissues, was upregulated 2.5-fold. Additionally, the RAD51 expression was significantly associated with the T stage (p = 0.027). According to a higher T stage, the RAD51 expression showed an increasing trend. However, the RAD51 expression did not show a prognostic value statistically. Conclusions: We confirmed that RAD51 was upregulated in tumors and was significantly associated with the T stage. Although there was no statistically significant prognostic value found in our samples and TGCA data, our study will provide new insight for RAD51 in CRC.
Keywords
RAD51colorectal cancerdouble-stand breakscancer prognosisclinical analysis
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/42738
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
Keimyung Author(s)
이재호
Full Text
https://www.mdpi.com/1010-660X/56/2/48
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