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Clinicopathological and Prognostic Characteristics of RAD51 in Colorectal Cancer

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Author(s)
Jae-Ho LeeAn-Na BaeSoo-Jung Jung
Keimyung Author(s)
Lee, Jae Ho
Department
Dept. of Anatomy (해부학)
Journal Title
Medicina (Kaunas)
Issued Date
2020
Volume
56
Issue
2
Keyword
RAD51colorectal cancerdouble-stand breakscancer prognosisclinical analysis
Abstract
Background and Objectives:
RAD51 plays an essential role in DNA repair via homologous recombination. RAD51 facilitates strand transfer between interrupted sequences and their undamaged homologies. Therefore, we studied the RAD51 mRNA expression levels in colorectal cancer (CRC), and evaluated the clinicopathological and prognostic significance of RAD51.

Materials and Methods:
The RAD51 expression was examined in 48 CRCs and paired adjacent non-tumor tissues. We further evaluated the survival to determine the prognostic value of RAD51 in our CRC and The Cancer Genome Atlas (TCGA) data.

Results:
We confirmed that the RAD51 expression in tumor tissues, compared with that of paired non-tumor tissues, was upregulated 2.5-fold. Additionally, the RAD51 expression was significantly associated with the T stage (p = 0.027). According to a higher T stage, the RAD51 expression showed an increasing trend. However, the RAD51 expression did not show a prognostic value statistically.

Conclusions:
We confirmed that RAD51 was upregulated in tumors and was significantly associated with the T stage. Although there was no statistically significant prognostic value found in our samples and TGCA data, our study will provide new insight for RAD51 in CRC.
Keimyung Author(s)(Kor)
이재호
Publisher
School of Medicine (의과대학)
Citation
Jae-Ho Lee et al. (2020). Clinicopathological and Prognostic Characteristics of RAD51 in Colorectal Cancer. Medicina (Kaunas), 56(2), 48–48. doi: 10.3390/medicina56020048
Type
Article
ISSN
1010-660X
Source
https://www.mdpi.com/1010-660X/56/2/48
DOI
10.3390/medicina56020048
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42738
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
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