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The rs6265 Polymorphism of the BDNF Gene Is Related to Higher-Lethality Suicide Attempts in the Korean Population

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Author(s)
김희철
Alternative Author(s)
Kim, Hee Chul
Publication Year
2020
Keyword
Suicide attemptLethalityBrain derived neurotrophic factorGeners6265.
Abstract
Objective:
Since the risk of suicide cannot be predicted by clinical symptoms alone, and suicide is known to have a genetic component, the discovery of genetic markers that can predict the lethality of suicide attempts is a clinically important topic. There have been many studies aiming to determine whether the rs6265 polymorphism of the BDNF gene is associated with suicidality; however, the results have been mixed, and there have been few studies investigating the relationship between this polymorphism and suicide attempt lethality.

Methods:
We assessed suicide lethality in 258 individuals who had attempted suicide using the relative risk ratio (RRR) scale and by genotyping the rs6265 polymorphism of the BDNF gene.

Results:
The RRR score for suicide attempts was higher in subjects with Met/Val and Val/Val genotypes than in that with a Met/Met genotype (p=0.015). The RRR score for suicide attempts was also higher in Val allele carriers (Met/Val+Val/Val) than in Met/Met homozygotes (p=0.006).

Conclusion:
This study demonstrates the possibility that the rs6265 polymorphism of the BDNF gene could be used as a genetic marker to predict the lethality of suicide attempts, but more replication studies are needed for the application of this result in clinical practice.
Department
Dept. of Psychiatry (정신건강의학)
Publisher
School of Medicine (의과대학)
Citation
PSYCHIATRY INVESTIGATION, Vol.17(5) : 417-423, 2020
Type
Article
ISSN
1976-3026
DOI
10.30773/pi.2020.0012
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/42771
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