계명대학교 의학도서관 Repository

Multiple Functions of Fubp1 in Cell Cycle Progression and Cell Survival

Metadata Downloads
Affiliated Author(s)
이재호
Alternative Author(s)
Lee, Jae Ho
Journal Title
Cells
ISSN
2073-4409
Issued Date
2020
Keyword
Fubp1cell cyclecyclin Acell deathlung cancerdouble-agent
Abstract
The discovery of novel and critical genes implicated in malignant development is a topic of high interest in cancer research. Intriguingly, a group of genes named "double-agent" genes were reported to have both oncogenic and tumor-suppressive functions. To date, less than 100 "double-agent" genes have been documented. Fubp1 is a master transcriptional regulator of a subset of genes by interacting with a far upstream element (FUSE). Mounting evidence has collectively demonstrated both the oncogenic and tumor suppressive roles of Fubp1 and the debate regarding its roles in tumorigenesis has been around for several years. Therefore, the detailed molecular mechanisms of Fubp1 need to be determined in each context. In the present study, we showed that the Fubp1 protein level was enriched in the S phase and we identified that Fubp1 deficiency altered cell cycle progression, especially in the S phase, by downregulating the mRNA expression levels of Ccna genes encoding cyclin A. Although this Fubp1-cyclin A axis appears to exist in several types of tumors, Fubp1 showed heterogeneous expression patterns among various cancer tissues, suggesting it exhibits multiple and complicated functions in cancer development. In addition, we showed that Fubp1 deficiency confers survival advantages to cells against metabolic stress and anti-cancer drugs, suggesting that Fubp1 may play both positive and negative roles in malignant development.
Department
Dept. of Anatomy (해부학)
Publisher
School of Medicine (의과대학)
Citation
Mingyu Kang. (2020). Multiple Functions of Fubp1 in Cell Cycle Progression and Cell Survival. Cells, 9(6), 1347-. doi: 10.3390/cells9061347
Type
Article
DOI
10.3390/cells9061347
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/43011
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
Authorize & License
  • AuthorizeOpen
Files in This Item:

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.