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Multiple Functions of Fubp1 in Cell Cycle Progression and Cell Survival

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Author(s)
Mingyu KangHyeon Ji KimTae-Jun KimJin-Seok ByunJae-Ho LeeDeok Heon LeeWanil KimDo-Yeon Kim
Keimyung Author(s)
Lee, Jae Ho
Department
Dept. of Anatomy (해부학)
Journal Title
Cells
Issued Date
2020
Volume
9
Issue
6
Keyword
Fubp1cell cyclecyclin Acell deathlung cancerdouble-agent
Abstract
The discovery of novel and critical genes implicated in malignant development is a topic of high interest in cancer research. Intriguingly, a group of genes named "double-agent" genes were reported to have both oncogenic and tumor-suppressive functions. To date, less than 100 "double-agent" genes have been documented. Fubp1 is a master transcriptional regulator of a subset of genes by interacting with a far upstream element (FUSE). Mounting evidence has collectively demonstrated both the oncogenic and tumor suppressive roles of Fubp1 and the debate regarding its roles in tumorigenesis has been around for several years. Therefore, the detailed molecular mechanisms of Fubp1 need to be determined in each context. In the present study, we showed that the Fubp1 protein level was enriched in the S phase and we identified that Fubp1 deficiency altered cell cycle progression, especially in the S phase, by downregulating the mRNA expression levels of Ccna genes encoding cyclin A. Although this Fubp1-cyclin A axis appears to exist in several types of tumors, Fubp1 showed heterogeneous expression patterns among various cancer tissues, suggesting it exhibits multiple and complicated functions in cancer development. In addition, we showed that Fubp1 deficiency confers survival advantages to cells against metabolic stress and anti-cancer drugs, suggesting that Fubp1 may play both positive and negative roles in malignant development.
Keimyung Author(s)(Kor)
이재호
Publisher
School of Medicine (의과대학)
Citation
Mingyu Kang et al. (2020). Multiple Functions of Fubp1 in Cell Cycle Progression and Cell Survival. Cells, 9(6), 1347. doi: 10.3390/cells9061347
Type
Article
ISSN
2073-4409
Source
https://www.mdpi.com/2073-4409/9/6/1347/htm
DOI
10.3390/cells9061347
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43011
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
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