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Associations of IL1RAP and IL1RL1 gene polymorphisms with obesity and inflammation mediators

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Affiliated Authors
송대규신동훈
Alternative Author(s)
Song, Dae KyuShin, Dong Hoon
Journal Title
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
ISSN
1420-908X
Issued Date
2020
Keyword
ObesityIL1RAPIL1RL1PolymorphismsInfammation
Abstract
Objectives:
Obesity is attributable to high free fatty acids, ER stress, oxidative stress and inflammation. The expression of IL-33, IL-1RL1 and IL-1RAP gene was observed in human visceral white fats, pre-adipocytes and adipocytes. The aim of this study was to determine whether IL1RAP and IL1RL1 gene variants were associated with obesity and inflammation mediators.

Methods:
3 SNPs of IL1RAP (rs9990107, rs3836449 and rs9290936) and 11 SNPs of IL1RL1 (rs3771180, rs13431828, rs3214363, rs1420101, rs12905, rs3771175, rs3821204, rs12712142, rs10204137, rs4988958, and rs10206753) were genotyped for 175 obesity (BMI ≥ 25) and 358 non-obesity (BMI < 25.0) subjects. The genotype of SNPs was determined by the Axiom Genome-Wide Human Assay.

Results:
The allele and genotype frequencies of 2 SNPs in the IL1RAP gene (rs9990107 and rs3836449) and 11 SNPs in the IL1RL1 gene (rs3771180, rs13431828, rs3214363, rs1420101, rs12905, rs3771175, rs3821204, rs12712142, rs10204137, rs4988958 and rs10206753) were significantly associated between the obesity and non-obesity groups. The two haplotypes (GCTTATGAATT and TT-CGACCGCC) in block1 were associated with obesity. In the non-obesity group, genotype frequencies of rs3771180, rs13431828, rs3214363, rs10204137, rs4988958 and rs10206753 SNPs of IL1RL1 showed significant differences in the dominant models in lymphatic cell percentage. The genotype frequencies of rs1420101, rs21905, rs3821024 and rs12712142 SNPs of IL1RL1 showed significant differences in the dominant models in eosinophil percentage.

Conclusions:
Our results suggest that IL1RAP and IL1RL1 gene polymorphisms may be associated with obesity and inflammation mediators.
Department
Dept. of Physiology (생리학)
Dept. of Preventive Medicine (예방의학)
Publisher
School of Medicine (의과대학)
Citation
Gyeong Im Yu. (2020). Associations of IL1RAP and IL1RL1 gene polymorphisms with obesity and inflammation mediators. Inflammation research : official journal of the European Histamine Research Society ... [et al.]., 69(2), 191-202. doi: 10.1007/s00011-019-01307-y
Type
Article
DOI
10.1007/s00011-019-01307-y
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/43098
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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