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Clinical Characteristics of Mitochondrial DNA Copy Number in Osteonecrosis of the Femoral Head

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Affiliated Author(s)
이시욱이경재김범수이재호
Alternative Author(s)
Lee, Si WookLee, Kyung JaeKim, Beom SooLee, Jae Ho
Journal Title
Medicina (Kaunas, Lithuania)
ISSN
1648-9144
Issued Date
2020
Keyword
mtDNAmtDNA-CNONFHosteonecrosismitochondrial DNAESRmtDNA copy number
Abstract
Background and objectives:
Alterations in mitochondrial DNA (mtDNA) have been observed and studied in various diseases. However, the clinical value of the mtDNA copy number (mtDNA-CN) alterations in osteonecrosis of the femoral head (ONFH) is poorly understood. In the present study, we investigated whether alterations in mtDNA-CNs are associated with clinicopathological parameters in ONFH.

Materials and methods:
MtDNA-CNs in the synovial tissue of 34 patients with ONFH and 123 control tissues (femoral neck fracture) were measured using quantitative real-time PCR. The present study then analyzed the correlation between the mtDNA-CN and the clinicopathological characteristics of ONFH and fracture patients.

Results:
The average mtDNA-CN (mean ± standard deviation) was 23.82 ± 22.37 and 25.04 ± 24.27 in ONFH and control tissues, respectively, and was not significantly different between the groups (p = 0.792). The mtDNA-CN was positively associated with age (27.7% vs. 45.9%, p = 0.018) and negatively associated with the erythrocyte sedimentation rate (ESR) (11.8% vs. 39.7%, p = 0.024) in all of the samples. The study also found further associations with age (22.2% vs. 68.8%, p = 0.014), gender (30.0% vs. 64.3%, p = 0.048), and ESR (0% vs. 57.7%, p = 0.043) in ONFH.

Conclusions:
in this study, we demonstrated that mtDNA-CN might be a significant marker for predicting clinical characteristics in ONFH.
Department
Dept. of Orthopedic Surgery (정형외과학)
Dept. of Anatomy (해부학)
Publisher
School of Medicine (의과대학)
Citation
Si-Wook Lee. (2020). Clinical Characteristics of Mitochondrial DNA Copy Number in Osteonecrosis of the Femoral Head. Medicina (Kaunas, Lithuania), 56(5), 239-. doi: 10.3390/medicina56050239
Type
Article
DOI
10.3390/medicina56050239
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/43238
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학)
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