Clinical Characteristics of Mitochondrial DNA Copy Number in Osteonecrosis of the Femoral Head
- Affiliated Author(s)
- 이시욱; 이경재; 김범수; 이재호
- Alternative Author(s)
- Lee, Si Wook; Lee, Kyung Jae; Kim, Beom Soo; Lee, Jae Ho
- Journal Title
- Medicina (Kaunas, Lithuania)
- ISSN
- 1648-9144
- Issued Date
- 2020
- Keyword
- mtDNA; mtDNA-CN; ONFH; osteonecrosis; mitochondrial DNA; ESR; mtDNA copy number
- Abstract
- Background and objectives:
Alterations in mitochondrial DNA (mtDNA) have been observed and studied in various diseases. However, the clinical value of the mtDNA copy number (mtDNA-CN) alterations in osteonecrosis of the femoral head (ONFH) is poorly understood. In the present study, we investigated whether alterations in mtDNA-CNs are associated with clinicopathological parameters in ONFH.
Materials and methods:
MtDNA-CNs in the synovial tissue of 34 patients with ONFH and 123 control tissues (femoral neck fracture) were measured using quantitative real-time PCR. The present study then analyzed the correlation between the mtDNA-CN and the clinicopathological characteristics of ONFH and fracture patients.
Results:
The average mtDNA-CN (mean ± standard deviation) was 23.82 ± 22.37 and 25.04 ± 24.27 in ONFH and control tissues, respectively, and was not significantly different between the groups (p = 0.792). The mtDNA-CN was positively associated with age (27.7% vs. 45.9%, p = 0.018) and negatively associated with the erythrocyte sedimentation rate (ESR) (11.8% vs. 39.7%, p = 0.024) in all of the samples. The study also found further associations with age (22.2% vs. 68.8%, p = 0.014), gender (30.0% vs. 64.3%, p = 0.048), and ESR (0% vs. 57.7%, p = 0.043) in ONFH.
Conclusions:
in this study, we demonstrated that mtDNA-CN might be a significant marker for predicting clinical characteristics in ONFH.
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