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Clinical Characteristics of Mitochondrial DNA Copy Number in Osteonecrosis of the Femoral Head

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Author(s)
Si-Wook Lee Kyung-Jae Lee Beom-Soo Kim Hyuk-Jun Kwon Jae-Ho Lee
Keimyung Author(s)
Lee, Si WookLee, Kyung JaeKim, Beom SooLee, Jae Ho
Department
Dept. of Orthopedic Surgery (정형외과학)
Dept. of Anatomy (해부학)
Journal Title
Medicina (Kaunas, Lithuania)
Issued Date
2020
Volume
56
Issue
5
Keyword
mtDNAmtDNA-CNONFHosteonecrosismitochondrial DNAESRmtDNA copy number
Abstract
Background and objectives:
Alterations in mitochondrial DNA (mtDNA) have been observed and studied in various diseases. However, the clinical value of the mtDNA copy number (mtDNA-CN) alterations in osteonecrosis of the femoral head (ONFH) is poorly understood. In the present study, we investigated whether alterations in mtDNA-CNs are associated with clinicopathological parameters in ONFH.

Materials and methods:
MtDNA-CNs in the synovial tissue of 34 patients with ONFH and 123 control tissues (femoral neck fracture) were measured using quantitative real-time PCR. The present study then analyzed the correlation between the mtDNA-CN and the clinicopathological characteristics of ONFH and fracture patients.

Results:
The average mtDNA-CN (mean ± standard deviation) was 23.82 ± 22.37 and 25.04 ± 24.27 in ONFH and control tissues, respectively, and was not significantly different between the groups (p = 0.792). The mtDNA-CN was positively associated with age (27.7% vs. 45.9%, p = 0.018) and negatively associated with the erythrocyte sedimentation rate (ESR) (11.8% vs. 39.7%, p = 0.024) in all of the samples. The study also found further associations with age (22.2% vs. 68.8%, p = 0.014), gender (30.0% vs. 64.3%, p = 0.048), and ESR (0% vs. 57.7%, p = 0.043) in ONFH.

Conclusions:
in this study, we demonstrated that mtDNA-CN might be a significant marker for predicting clinical characteristics in ONFH.
Keimyung Author(s)(Kor)
이시욱
이경재
김범수
이재호
Publisher
School of Medicine (의과대학)
Citation
Si-Wook Lee et al. (2020). Clinical Characteristics of Mitochondrial DNA Copy Number in Osteonecrosis of the Femoral Head. Medicina (Kaunas, Lithuania), 56(5), 239. doi: 10.3390/medicina56050239
Type
Article
ISSN
1648-9144
Source
https://www.mdpi.com/1648-9144/56/5/239
DOI
10.3390/medicina56050239
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43238
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학)
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