계명대학교 의학도서관 Repository

β-hydroxybutyrate Impedes the Progression of Alzheimer's Disease and Atherosclerosis in ApoE-Deficient Mice

Metadata Downloads
Author(s)
Manigandan Krishnan Jong Su HwangMikyung KimYun Jin KimJi Hae SeoJeeyoun Jung Eunyoung Ha 
Keimyung Author(s)
Seo, Ji HyeHa, Eun Young
Department
Dept. of Biochemistry (생화학)
Journal Title
Nutrients
Issued Date
2020
Volume
12
Issue
2
Keyword
Alzheimer's diseaseβ-hydroxybutyrateatherosclerosischoroid plexusapolipoprotein-E
Abstract
β-hydroxybutyrate (β-OHB) has been shown to exert an anti-inflammatory activity. Apolipoprotein-E (ApoE) is strongly associated with atherosclerosis and Alzheimer's disease (AD). This study aimed to explore the therapeutic effect of β-OHB in the brain and the aorta of high-fat diet (HFD)-fed ApoE-deficient mice. We found in Apo-E deficient mice that β-OHB attenuated lipid deposition in the choroid plexus (ChP) and decreased amyloid plaque in the substantia nigra pars compacta. We also found decreased CD68-positive macroglia infiltration of the ChP in β-OHB-treated ApoE-deficient mice. β-OHB treatment ameliorated IgG extravasation into the hippocampal region of the brain. In vitro study using ChP mice cell line revealed that β-OHB attenuated oxidized low-density lipoprotein-induced ApoE-specific differentially expressed inflammatory ChP genes. Treatment with β-OHB reduced aortic plaque formation without affecting blood lipid profiles and decreased serum production of resistin, a well-established risk factor for both AD and atherosclerosis. Thus, the current study suggests and describes the therapeutic potential of β-OHB for the treatment of AD and atherosclerosis.
Keimyung Author(s)(Kor)
서지혜
하은영
Publisher
School of Medicine (의과대학)
Citation
Manigandan Krishnan et al. (2020). β-hydroxybutyrate Impedes the Progression of Alzheimer’s Disease and Atherosclerosis in ApoE-Deficient Mice. Nutrients, 12(2), 471. doi: 10.3390/nu12020471
Type
Article
ISSN
2072-6643
Source
https://www.mdpi.com/2072-6643/12/2/471
DOI
10.3390/nu12020471
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43260
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.