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Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway

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Affiliated Author(s)
이재호장병국김미경
Alternative Author(s)
Lee, Jae HoJang, Byoung KukKim, Mi Kyung
Journal Title
Int J Mol Sci
ISSN
1422-0067
Issued Date
2021
Keyword
kahweolSrc kinaseHCCapoptosis
Abstract
Kahweol, a coffee-specific diterpene, induces apoptosis in human cancer cells, and some targets of kahweol-mediated apoptosis have been identified. However, the specific apoptotic effects and mechanism of action of kahweol in hepatocellular carcinoma (HCC) cells are unknown. This study was performed to investigate the molecular mechanism by which kahweol induces apoptosis in HCC cells. The Src pathway is associated with apoptosis in cancer. In this study, we found that kahweol induces apoptosis by inhibiting phosphorylation of Src, and also inhibiting p-mTOR and p-STAT3. Therefore, we suggest that kahweol is a potent inhibitor of HCC cell growth.
Department
Dept. of Anatomy (해부학)
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine (의과대학)
Citation
Hye-Young Seo. (2021). Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway. Int J Mol Sci, 22(19), 10509 10.3390/ijms221910509
Type
Article
DOI
10.3390/ijms221910509
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/44033
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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