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Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway

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Author(s)
Hye-Young SeoSo-Hee LeeJi-Ha LeeJae-Ho LeeByoung Kuk JangMi Kyung Kim
Keimyung Author(s)
Lee, Jae HoJang, Byoung KukKim, Mi Kyung
Department
Dept. of Anatomy (해부학)
Dept. of Internal Medicine (내과학)
Journal Title
Int J Mol Sci
Issued Date
2021
Volume
22
Issue
19
Keyword
kahweolSrc kinaseHCCapoptosis
Abstract
Kahweol, a coffee-specific diterpene, induces apoptosis in human cancer cells, and some targets of kahweol-mediated apoptosis have been identified. However, the specific apoptotic effects and mechanism of action of kahweol in hepatocellular carcinoma (HCC) cells are unknown. This study was performed to investigate the molecular mechanism by which kahweol induces apoptosis in HCC cells. The Src pathway is associated with apoptosis in cancer. In this study, we found that kahweol induces apoptosis by inhibiting phosphorylation of Src, and also inhibiting p-mTOR and p-STAT3. Therefore, we suggest that kahweol is a potent inhibitor of HCC cell growth.
Keimyung Author(s)(Kor)
이재호
장병국
김미경
Publisher
School of Medicine (의과대학)
Citation
Hye-Young Seo et al. (2021). Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway. Int J Mol Sci, 22(19), 10509. doi: 10.3390/ijms221910509
Type
Article
ISSN
1422-0067
Source
https://www.mdpi.com/1422-0067/22/19/10509
DOI
10.3390/ijms221910509
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44033
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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