Association between Visceral Adipose Tissue Metabolism and Alzheimer's Disease Pathology
- Affiliated Author(s)
- 김신; 이현아; 원경숙; 김해원
- Alternative Author(s)
- Kim, Shin; Yi, Hyon Ah; Won, Kyoung Sook; Kim, Hae Won
- Journal Title
- Metabolites
- ISSN
- 2218-1989
- Issued Date
- 2022
- Keyword
- adipose tissue; Alzheimer’s disease; amyloid-β; glucose metabolism
- Abstract
- The visceral adipose tissue (VAT) has been recognized as an endocrine organ, and VAT dysfunction could be a risk factor for Alzheimer’s disease (AD). We aimed to evaluate the association of VAT metabolism with AD pathology. This cross-sectional study included 54 older subjects with cognitive impairment who underwent 2-deoxy-2-[fluorine-18]-fluoro-D-glucose (18F-FDG) torso positron emission tomography (PET) and 18F-florbetaben brain PET. 18F-FDG uptake in VAT on 18F-FDG PET images was used as a marker of VAT metabolism, and subjects were classified into high and low VAT metabolism groups. A voxel-based analysis revealed that the high VAT metabolism group exhibited a significantly higher cerebral amyloid-β (Aβ) burden than the low VAT metabolism group. In the volume-of-interest analysis, multiple linear regression analyses with adjustment for age, sex, and white matter hyperintensity volume revealed that 18F-FDG uptake in VAT was significantly associated with the cerebral Aβ burden (β = 0.359, p = 0.007). In conclusion, VAT metabolism was associated with AD pathology in older subjects. Our findings suggest that VAT dysfunction could contribute to AD development.
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