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Association between Visceral Adipose Tissue Metabolism and Alzheimer's Disease Pathology

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Author(s)
Shin KimHyon-Ah YiKyoung Sook WonJi Soo LeeHae Won Kim
Keimyung Author(s)
Kim, ShinYi, Hyon AhWon, Kyoung SookKim, Hae Won
Department
Dept. of Immunology (면역학)
Dept. of Neurology (신경과학)
Dept. of Nuclear Medicine (핵의학)
Journal Title
Metabolites
Issued Date
2022
Volume
12
Issue
3
Keyword
adipose tissueAlzheimer’s diseaseamyloid-βglucose metabolism
Abstract
The visceral adipose tissue (VAT) has been recognized as an endocrine organ, and VAT dysfunction could be a risk factor for Alzheimer’s disease (AD). We aimed to evaluate the association of VAT metabolism with AD pathology. This cross-sectional study included 54 older subjects with cognitive impairment who underwent 2-deoxy-2-[fluorine-18]-fluoro-D-glucose (18F-FDG) torso positron emission tomography (PET) and 18F-florbetaben brain PET. 18F-FDG uptake in VAT on 18F-FDG PET images was used as a marker of VAT metabolism, and subjects were classified into high and low VAT metabolism groups. A voxel-based analysis revealed that the high VAT metabolism group exhibited a significantly higher cerebral amyloid-β (Aβ) burden than the low VAT metabolism group. In the volume-of-interest analysis, multiple linear regression analyses with adjustment for age, sex, and white matter hyperintensity volume revealed that 18F-FDG uptake in VAT was significantly associated with the cerebral Aβ burden (β = 0.359, p = 0.007). In conclusion, VAT metabolism was associated with AD pathology in older subjects. Our findings suggest that VAT dysfunction could contribute to AD development.
Keimyung Author(s)(Kor)
김신
이현아
원경숙
김해원
Publisher
School of Medicine (의과대학)
Citation
Shin Kim et al. (2022). Association between Visceral Adipose Tissue Metabolism and Alzheimer’s Disease Pathology. Metabolites, 12(3), 258. doi: 10.3390/metabo12030258
Type
Article
ISSN
2218-1989
Source
https://www.mdpi.com/2218-1989/12/3/258
DOI
10.3390/metabo12030258
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44283
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
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