Function of gaseous hydrogen sulfide in liver fibrosis
- Affiliated Author(s)
- 임승순
- Alternative Author(s)
- Im, Seung Soon
- Journal Title
- BMB Rep
- ISSN
- 1976-670X
- Issued Date
- 2022
- Keyword
- CBS; CSE; Hydrogen sulfide; Liver fibrosis; Metabolism; MPST
- Abstract
- Over the past few years, hydrogen sulfide (H2S) has been shown to exert several biological functions in mammalian. The endogenous production of H2S is mainly mediated by cystathione β-synthase, cystathione γ-lyase and 3-mercaptopyruvate sulfur transferase. These enzymes are broadly expressed in liver tissue and regulates liver function by working on a variety of molecular targets. As an important regulator of liver function, H2S is critically involved in the pathogenesis of various liver diseases, such as non-alcoholic steatohepatitis and liver cancer. Targeting H2S-generating enzymes may be a therapeutic strategy for controlling liver diseases. This review described the function of H2S in liver disease and summarized recent characterized role of H2S in several cellular process of the liver.
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