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Function of gaseous hydrogen sulfide in liver fibrosis

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Author(s)
Jae-Ho LeeSeung-Soon Im
Keimyung Author(s)
Im, Seung Soon
Department
Dept. of Physiology (생리학)
Journal Title
BMB Rep
Issued Date
2022
Volume
55
Issue
10
Keyword
CBSCSEHydrogen sulfideLiver fibrosisMetabolismMPST
Abstract
Over the past few years, hydrogen sulfide (H2S) has been shown to exert several biological functions in mammalian. The endogenous production of H2S is mainly mediated by cystathione β-synthase, cystathione γ-lyase and 3-mercaptopyruvate sulfur transferase. These enzymes are broadly expressed in liver tissue and regulates liver function by working on a variety of molecular targets. As an important regulator of liver function, H2S is critically involved in the pathogenesis of various liver diseases, such as non-alcoholic steatohepatitis and liver cancer. Targeting H2S-generating enzymes may be a therapeutic strategy for controlling liver diseases. This review described the function of H2S in liver disease and summarized recent characterized role of H2S in several cellular process of the liver.
Keimyung Author(s)(Kor)
임승순
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1976-670X
Source
https://www.bmbreports.org/journal/view.html?doi=10.5483/BMBRep.2022.55.10.124
DOI
10.5483/BMBRep.2022.55.10.124
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44507
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
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