자궁경부선암에서의 고위험군 인유두종바이러스의 동정

Abstract

조직학적으로 자궁경부선암으로 확진된 환자를 대상으로 임상적 예후를 알아보고 또 HPV DNA chip 검사를 실시하여 HPV 아형분포와 HPV 다중감염의 유형을 살펴보고자 하였다 대구 동산의료원 산부인과학교실에서 조직학적으로 자궁경부선암으로 확진된 87명의 환자를 대상으로 후향적으로 임상양상을 조사하고 HPV DNA chip 검사를 시행하여 HPV 아형과 다중감염의 정도를 조사하였다 환자 87명의 평균나이는 48.7세였으며, FIGO 분류에 따른 병기는 I기 환자가 63명으로 가장 많았으며 2기 환자가 18명, 3기 환자가 6명이였다. 자궁경부선암에서의 HPV 감염은 87명중 60명이 감염된 상태를 나타내어 감염율은 68.9%(60명/87명)이였으며, 18 아형이 가장 많았고(34명), 16 아형(20명), 45 아형(2명), 52 아형(1명), 16번과 18번 중복 감염(3명)으로 나타났다. 본원의 자궁경부선암의 HPV 아형 감염은 2/3정도에서 확인되었으며, HPV 감염은 아형 18, 16, 45형 순으로 나타났다. 중복 감염은 5%(3명/60명)로 확인되었다. This study was performed to investigate the genotypes of human paillomavirus and its multiple infections in patients with cervical adenocarcinoma, and the commercially available HPV DNA chip was used. Retrospectively cervical specimens of 87 patients with pathologically, confirmed cervical adenocarcinoma were tested for HPV genotyping performed by HPV DNA chip method in Keimyung University Medical School. This study will examined the frequency of human paillomavirus genotypes and its multiple infections The mean age of 87 patients was 48.7years. Tumors were classified (FIGO staging) as stage I in 63 patients, stage II in 18 patients, and stage III in 6 patients. Among the 87 patients 60 (68.9%) were tested positive for HPV DNA. The most prevelent single HPV infection type was HPV-18 in 34 patients. HPV-16 was detected in 20 patients, HPV-45 in 2 patients, and HPV-52 in 1 patient. Multiple HPV infection were detected in 3 patients, and the majority of the common coinfection were identified as HPV types 16/18. Our study demonstrates that the positive rate of high risk HPV infection was 68.9% in cervical adenocarcinoma. We found that HPV-18 was the most prevalent, followed by HPV-16, HPV-45 and HPV 52. Multiple HPV infection rate was 5% in cervical adenocarcinoma.