수종 자궁수축제의 마우스의 적출자궁 수축력에 미치는 효과의 비교

Abstract

The response of the isolated uterus from pregnant (gestational period less than 10 days) and nonpregnant mouse to uterine stimulants, oxytocin, prostaglandin F₂α (PGF₂α )and ergonovine, was observed in low calcium Tyrode's solution. Potency was represented by the value of pD₂ which is defined as the negative logarithm of the concentration producting half- maximal response to each drug. In the non-pregnant uterus, the pD₂ values of oxytocin, PGF₂α, and ergonovine were 8.86, 6.76, and 6.70, respectively. In the pregnant uterus, the values were 8.45, 7.50, and 7.75, respectively. A maximal response produced by oxytocin was similar to that by PGF₂α in both pregnant and nonpregnant uterus. However, the maximal response to ergonovine in the nonpregnant uterus was one-twenty fifth the response to oxytocin and PGF₂α, and in the pregnant uterus it was a half the response to them.