원발성 위장관 림프종의 임상적 고찰

Abstract

A clinical study was carried out retrospectively on 14 patients with primary intestinal lymphoma who admitted to the Dong San Hospital, Keimyung University between Jan. 1972 and December 1983. The results of the this study was as follows.

1. Male to female ratio was 13 ： 1 with male predominance and the age distribution was between 3 and 68 with mean age of 33,7 years.

2. Abdominal pain was the most frequent complaint(12 cases: 85.7%). Abdominal mass was observed in 6 cases (42.9%), fever in 3 cases(21.4%), weight loss in 2 cases (14.3%), diarrhea in 2 cases (14.3%) and general weakness, anorexia, constipation and nausea in 1 case(7,1 %) respectively.

3. Laboratory findings revealed anemia in 35.7%, leukocytosis in 28.6%, lymphopenia in 28. 6%， hypoproteinmia in 14.3%, azotemia in 7,1% and increased alkaline phosphatase in 7.1%.

4. Sites of involvement were as follows:

Cecum in 8 cases(57.1%), ileum in 6 cases(42.9%), ascending colon in 4 cases(28.6%) and stomach, jejunum, appendix, rectum in 1 case(7.1%) in each respectively.

5. Histopathologic classifications were as follows:

Non-Hodgkin's lymphoma was 12 cases(5 cases of histiocytic type, 3 of mixed cellularity, 2 of well-differentiated and 2 of poorly differentiated lymphocytic type) and Hodgkin’s disease was 2 cases (all in lymphocytic depletion type).

6. By Ann Arbor staging, stage I in 4 cases(28.6%), stage D in 7(50%). Stage I 1(7.1%) and stage F in 2(14.3%).

7. Treatment was performed as follows: Radiotherapy in 5 cases, chemotherapy in 7 cases, chemotherapy in 7 cases and combined modality therapy in 1 case.

8. Follow-up study of 13 cases revealed complete remission in 6 cases(46.1%) and partial remission in 4(30.8%).