Hodgkin 씨 병에 대한 임상적 고찰

Abstract

A clinical study was carried out retrospectively on 24 patients with Hodgkin's disease who admitted to the Dong San Hospital, Keimyung University between May, 1972 and December, 1983. The rerults of the this study was as follows.

Male to female ratio was 5 ： 1 with male predominance and the age distribution was between 5 and 63 with mean age of 29.9 years.

Palpable neck mass was the most frequent complaint(20 cases: 83.3%). General weakness, fever was observed in 7 cases(29.2%) and weight loss, abdominal pain in 5 cases(20. 8%), respectively.

Physical findings revealed lymph node enlargement in 23 cases(95.8%) with cervical, inguinal, axillary and mesenteric in order of frequency. Splenomegaly was observed in 10 cases (41.7%), hepatomegaly in 7 cases(29.2%) and abdominal mass in 5 cases(20.8%).

Laboratory findings revealed anemia in 45.8%, leukopenia in 16.7%, leukocytosis in 16.7%, thrombocytopenia in 4.5%, hypoproteinemia in 22.7%, azotemia in 13.6%, increased alkaline phosphatase in 18.2% and hypercalcemia in 7.1%.

Histopathologic classifications by Rye modification were as follows: Lymphocyte predominance was 3 cases(16.7%), nodular sclerosis 3 cases(16.7%), mixed cellularity 10 cases(55.6%) and lymphocyte depletion was 2 cases(ll. 1%). By Ann Arbor staging, stage I in 4 cases(16.7%), stage II in 10 cases(41.7%), stage I in 6 cases(25%), stage F in 4 cases(16.7%).

Treatment was performed as follows: Radiotherapy in 7 cases, chemotherapy in 9 cases, combined therapy in 2 cases and operatin was done in 5 cases.

Long-term follow up cases for over two years were 6 cases and a half of these cases were achieved complete remission.