흰쥐 재생간의 Leucine Aminopeptidase의 활성치

Abstract

Changes in the activities of the followings have been studied over a period of 6 days after partial hepatectomy in rats: Plasma membrane, mitochondrial, nuclear and cytosolic leucine aminopeptidase and microsomal-particle bound aminopeptidase of the regenerating liver and serum leucine aminopeptidase. The activities of alkaliine phosphatase in the subcellular fractions were also measured. The activities of leucine aminopeptidase and alkaline phosphatase in serum markedly elevated from 12 hours to three days after partial hepatectomy in rats. The activity of plasma memberane-bound leucine aminopeptidase in the regenerating rat liver drastically increased during the first and the third days of the operation. And the activity of microsomal particle-bound aminopeptidase in the regenerating liver significantly increased between the second and the third days after operation. The activities of nuclear and cytosolic leucine aminopeptidase in the regenerating liver showed a substantial increase at the second day and from first to sixth day respectively after operation. However, no significant change in hepatic mitochondrial leucine aminopeptidase was noted throughout the experiments. The activities of plasma membrane, microsomal, mitochondrial, nuclear and cytosolic alkaline phosphatase in the regenerating liver markedly increased throughout the experiments.