Metoclopramide에 의한 혈장 Corticosterone과 혈당치변동에 대한 Dexamethasone, Dopamine 및 Chlorpromazine의 영향

Abstract

Metoclopramide have dopaminergic antagonism, cholinergic properties and antiemetic effect so on. In this paper, actions of metoclopramide on the changes of plasma corticosterone and blood sugar level, and influences of dexamethasone, dopamine and chlorpromazine on those level induced by metoclopramide were studied in mice. The results obtained were summarized as follows; 1. The plasma corticosterone level was significantly increased by metoclopramide (20mg/kg, 40mg/kg and 60mg/kg), respectively. 2. The metoclopramide (20mg/kg, 40mg/kg and 60mg/kg)-induced increase of plasma corticosterone level was significantly inhibited by dexamethasone, dopamine and chlorpromazine, respectively. 3. The dopamine-induced change of plasma corticosterone level was slightly inhibited by dexamethasone, but chlorpromazine-induced change of plasma corticosterone level was significantly inhibited by it. 4. The blood sugar level was not affected by metoclopramide (20mg/kg and 40mg/kg) and dexamethasone, but significantly increased by metoclopramide (60mg/kg), dopamine and chlorpromazine. 5. The metoclopramide (60mg/kg)-induced increase of blood sugar level was not affected by dopamine, but significantly increased by dexamethasone and chlorpromazine. 6. The dopamine or chlorpromazine-induced increase of blood sugar level was not affected by dexamethasone. The above results suggest that the metoclopramide-induced increase of plasma corticoterone level is due to mainly dopaminergic antagonism and partly effect of ACTH on the adrenal cortex. But, interrelationships between changes of plasma corticosterone and blood sugar level induced by metoclopramide were not meaningful.