Hexafluorenium Bromide(Mylexa)가 Pseudochlinesterase Activity에 미치는 영향

Abstract

Hexafluorenium Bromider(Mylexan)? has an cation of a selective anticholinesterase with mild competitive enuromuscular blocking potency. It is well known ot prolong the blocking action of succinylcholine and to minimize the fasciculation. Howecer, it has not been popular in anesthesia practice. In this study, an attempt was made to observe the dehree of pseudocholinesterase activity depressed by intravenous administration of Mylexan. 20 patients scheduled for elective surgery were selected at randome and serum pseudocholinesterase activity was measured before administration of Mylexan for control group and was measured in 5 min, 10 min, 15 min, 20 min, 25 min and 30 minutes after administration of mylexan. The results were as follows: The mean value was 919.2 IU/L(international unit/liter) in control group, 453.5IU in 5 min, 568.6IU in 10 min, 672.8IU in 15 min, 719.2IU in 20 min, 693.7IU in 25 min, and 721.0IU in 30 min. According to the data, serum pseudocholinesterase activity decreased lowest at 5 min than increased gradually to the normal boundary until 30 min after administration of Mylexan.