두경부암의 염색체연구

Abstract

The auther was pel'ormed chromosome analysis from the patients with laryngeal cancer and nasopharyngeal cancer with newly development technique for cell segregation by using enzyme treated method. Segregated cells were incubated for overnight and chromosomes were obtained with routine fixation and stainning methods. The results are summerized as follows A structural abnormality involving chromosome 1 with break point located on long arm was found in the laryngeal cancer and in the nasopharyngeal cancer break points were found on distal segment of short arm in chromosome 3. The N-RAS and SK oncogenes are located near these segment of chromosome 1 and E-B virus is concerned with nasopharyngeal cancer. It should be confirmed to how develope the cancer in the future.