만성 골수성 백혈병(CML)에서 염색체의 변화

Abstract

This article documents the cytogenetic findings in 43 patients with chronic myelocytic leukemia (CML). Short term culture (3hr) of bone marrow of 26 males and 17 females were studied with different banding techniques. 8 cases were studied during blastic phase (BP), and the others were during chronic phase (CP). typical Philadelpia (PH¹) chromosomes [t(9 : 22) q34 : q11)] were present in 20 cases (47%). Variant was t(14:22) (q32 : q11), additional findings were＋8, -22q, -22, i(17q), hyperdiploidy. In BP, 2 cases were hyperdiploid, 2 cases were mosaic pattern, 2 cases had Ph¹ and additional findings (complex translocation), the others had typical Ph¹ alone. Authers discussed the relevance of chromosome change and break point. Certain chromosome regions are more often affected. These might contain genes of critical importance for the final malignant progression. Molecular biology may provide insight on the nature and expression of involved genes.