미만성 조직구성 림프종의 임상적고찰

Abstract

A retrospective review is presented for 70 previously untreated adult patients with diffuse histiocytic lymphoma between March 1980 through March 1986 at the Keimyung University. The mean age was 51.4 years with a male to female ratio of 1.7:1. On admission, neck mass was the most frequent symptom in 31 cases(44%) and abdominal pain, fever, weight loss, dysphagia, anorexia, sore throat and abdominal distension were commonly presented. Physical findings revealed peripheral lymph node enlargement in 47 cases (67%) with cervical, inguinal, axillary in order of frequency. Abdominal mass was observed in 12 cases, hepatomegaly 12 cases and intussusception 2 cases and SVC syndrome, exophthalmos, scrotal mass in 1 case respetively. Extra-nodal involvement was 49 cases (70%) and GIT was most frequent site of involvement (15 cases). Laboratory findings revealed anemia in 33%, leukocytosis in 30%, leukopenia in 16%, thrombocytopenia in 7%, hypoproteinemia in 17%, increased alkaline phosphatase in 9% and increased SGOT in 20%. Local-regional involvement (stage Ⅰ-Ⅱ) occurred in 49% and advanced stage (stage Ⅲ-Ⅳ) in 51% and constitutional symptoms were associated with stage Ⅰ-Ⅱ in 15% stage Ⅲ-Ⅳ in 44%. Treatment was performed with radiotherapy in 12 cases, combination chemotherapy in 23 cases and combined modality therapy in 3 cases. Three year survival rate of complete responder is 92% and 3 year survival rate of local-regional disease was 82% and advanced disease was 33%.