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만성골수성 백혈병의 임상적 고찰

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Author(s)
여인석송홍석
Keimyung Author(s)
Song, Hong Suk
Department
Dept. of Internal Medicine (내과학)
Journal Title
Keimyung Medical Journal
Issued Date
1988
Volume
7
Issue
1
Abstract
A retrospective review is presented for 23 previously untreated patients with chronic myelogenous leukemia between July 1981 through July 1987 at the Keimyung University. The results of study were as follows: The mean age was 38 years with a male to female ratio of 1.1:1. On admission, LUQ mass was the most frequent complaint in 12 cases (52.2%) and easy fatigability, general weakness, bleeding, indigestion, weight loss were commonly presented on order of frequency. Physical finding revealed splenomegaly in all case, hepatomegaly in 10 cases(43.5%), and lymphadenopathy in 2 cases(8.7%). Hematologic finding revealed hematocrit below 11.9gm/dl in 87% with mean of 9.0(range: 5.1-14.0)gm/dl, leukocyte over 100,000/mm³ in 87% with mean of 241,200(range; 46,500--516,500)/mm³, and platelet over 800,000/mm³ in 22% with mean of 522,000(range: 170,000-1,112,000)/mm³. Bone marrow aspiration disclosed mean percentage of myeloblast was 3.5% and mean of myeloblast plus promyelocyte was 10.9%. Peripheral leukocytosis was deeply correlated with bone marrow immature cells(p<0.001), but did not relate to spleen size, degree of anemia, peripheral immature cells, and LDH(p,0.01). Cytogenetic study was performed in 10 cases, and there was Philadelphia chromosome in 6 cases, aneuploidy and double minute chromosome in one case, and normal study in 3 case, and one which performed in blastic phase revealed Ph¹, 8 trisomy, and I (17q). Three year survival rate of total 23 cases of busulfan-treated patient is 80% with mean survival time of 42 months, and there was no statistical significance between male and female group(p<0.1).
Alternative Title
Clinical Study of Chronic Myelogenous Leukemia
Keimyung Author(s)(Kor)
송홍석
Publisher
Keimyung University School of Medicine
Citation
여인석 and 송홍석. (1988). 만성골수성 백혈병의 임상적 고찰. Keimyung Medical Journal, 7(1), 136–145.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/14524
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 1988
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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