Platelets apheresis 수혈에 의한 혈소판 회복율

Abstract

To determine the reative importance of clinical factors on the efficacy of platelet transfusion, 37 random multipie-donor platelet concentrate transfusions and 91 random platelets apheresis transfusions were studied. One-hour and twenty four-hour corrected count increment(CCI) as efficacy of platelet transfusion were measured. Disease groups included acute lymphocytic leukemia, acute nonlympocytic leukemia, aplastic anemia, immune thrombocytopenic purpua, malignant tumor and others(panperitonitis, burn gall stone, liver cirrhosis and iron deficiency anemia). All disease groups except aplastic anemia group comparing with others group, showed significantly decreased efficacy of platelets apheresis transfusion, however there was no statistical singificance between disease groups. Patients with fever and/or splenomegaly showed significantly decreased efficacy of platelets apheresis transfusion. Patients with repeated platelet transfusion compared to patients without transfusion, showed decreased efficacy of platelet transfusion with statistica significance in fourth transfusions. In donors, after plateletpheresis using blood-cell separator(Haemonetics V50), hemoglobin level, WBC count, and platelet count were decreased 10.6%, 4.2%, and 31% respectively. And total platelet count in a platelets apheresis was approximately ten times more than in a platelet concentrate, however contaminating white blood cell count in platelets apheresis was signficantly higher than in platelet concentrate. The frequency of the refractoriness to multiple-donor platelet concentrate transfusions was higher than platelets apheresis transfusion. The findings of this study suggest that understanding the factors affecting the efficacy of platelet transfusion and the use of latelets apheresis are necessary to decrease refractoriness to platelet transfusion.