흰쥐 담즙울체간의 Glutathione S-Transferase, Glutathione Reductase 및 Glutathione Peroxidase의 활성도

Abstract

Changes in the activities of the following enzymes have been studied over a period of forty two days after the ligation of common bile duct in rats: cytosolic, mitochondrial and microsomal glutathione S-transferase, cytosolic glutathione reductase and cytosolic glutathione peroxidase of cholestatic liver. The activity of cytosolic glutathione S-transferase in the cholestatic rat liver strikingly diminished between the third and the forty-second days after the ligation of common bile duct and of mitochondrial glutathione S-transferase also showed significant decrease between the fourteenth and the forty-second days after operation. However, the microsomal glutathione S-transferase activity in the cholestatic rat liver showed a substantial increase between the seventh and twenty-eight days after operation. The cytosolic glutathione reductase activity in the cholstatic rat liver elevated considerably between the second and the forty-second days after operation, but the cytosolic glutathione peroxidase activity in the cholestatic rat liver had a significant diminution between the fourteenth and the forty-second days after the ligation of common bile duct.