Diffuse Well-Differentiated 림프구형 림프종에 대한 임상적고찰

Abstract

Diffuse well-differentiated lymphocytic lymphoma is a relatively rare form of non-Hodgkin's lymphoma. We have observed 9 cases of diffuse well-differentiated lymphocytic lymphoma from March 1980 to September 1989. The mean age was 42.4 years, with a male to female ratio of 2:1 Peripheral lymphadenopathy was found in 3 cases and extranodal manifestation was noted in 8 cases, and 6 cases were originated from extranodal sites: colon in 2 cases, ileum, conjunctiva, tonsil, testis in 1 case respectively. On admission, clinical stage was as follows: stage Ⅰ in 5 cases, stage Ⅱ in 2 cases, stage Ⅲ in 1 case, and stage Ⅳ in 1 case. All stage Ⅰ except one patient were treated by radiotherapy and 3 patients were treated with combination chemotherapy. Two cases were relapsed 4 and 62 months after treatment with histologic conversion to diffuse poorly differentiated type. 5 patients are still alive in 12, 20, 23, 41, 57 months with no evidence of disease.