다발성말초신경병증의 두발 중 납과 수은 함량 조사

Abstract

This study was carried out to investigate the correlation between lead and mercury contents and polyneuropathies(PN) as causing or concomitant causing factors. The subjects were divided into 3 experimental groups(total 60 cases, 35 males, 25 females), among whom were 32 etiologically undetermined PN(Group I, 18 males, 14 females), 21 diabetic PN(Group II, 10 males, 11 females) and 7 alcohlic PN(Group III, 7 males), and 38 healthy subjects(27 males, 11 females) as a control group. Occipital hair(about glm) were obtained from all experimental and control subjects to analyze lead and mercury contents(ppm) using an atomic absorption spectrophotometer, model IL. 551 connected with a CTF atomizer(IL. 655). The mean values of lead and mercury contents in hair were significantly more elevated in the etiologically undetermined PN group than in the control group(p<0.05, p<0.01), and there were significantly elevated mercury contents in the hair of the diadetic PN group(p<0.01) and lead contents in the hair of the alcoholic PN group(p<0.05). The mean values of lead and mercury contents had not significant correlation to motor nerve conduction velocity and there was no significant correlation of the mean values of lead or mercury contents between urban and rural residents. These results suggest that lead and mercury may be causative factors in the development of Group 1 PN, and lead and mercury may be concomitant causative factors in the development of II and Group III PN, respectively.