임상가검물에서 분리된 Gram음성 간균의 항균제감수성

Abstract

One hundred and one Gram negative bacilli isolated from various clinical specimens were tested for antimicrobial susceptibility to 21 drugs including quinolones. P. aeruginosa(35 strains) was most frequently isolated and followed by Proteus(27),E. coli(20), Klebsiella(16), Citrobacter(2), Serratia(1) in the decreasing order. The majority of strains isolated except P. aeruginosa were very susceptible to quinolone antibiotics tested. In P. aeruginosa all strains were resistant to nalidixic acid, and 11.4-17.1% to enoxacin, norfloxacin(NF), and ciprofloxacin. The other species had no resistant strains to Nf, and especially E. coli was very highly susceptible to all quinolone antibiotics tested. 90%MICs of quinolones against P. aeruginosa were 32-＞64 and the other species was ＜0.25-16. Resistance frequency of P. aeruginosa to beta-lactam antibiotics were 42.9-60% and 90% MICs of these drugs were also high. To amikacin, 51.4% of P. aeruginosa was resistant, but all strains of the other species were susceptible except one strain. The majority of isolated strains were susceptible to chloramphenicol, tetracycline, sulfisomidine, and trimethoprim. Organisms multiply resistant to drugs were noted in almost all isolates tested. The strain numbers of multiply resistant to 6 or more drugs were 16 strains of E. coli, 24 strains of P. aeruginosa, 16 strains of Proteus, 3 strains of Klebsiella.