혈소판 감소 환자들의 평균 혈소판용적과 혈소판용적 분포폭

Abstract

The quantitation of platelets in peripheral blood is a well recognized tool. However, other platelet parameters that recently have become available on a routine basis with the introduction of automated cell sizers may become increasingly important in evaluation the integrity of the thrombocytic function. These parameters include mean platelet volume, platelet distribution width and platelet-crit. The clinical usefulness of platelet parameters were examined in 373 unselected thrombocytopenic patients. Patients with thrombocytopenia resulting from loss or consumption have higher mean platelet volumes than do patients with marrow failure. Thrombocytopenic patients also have greater heterogeneity of platelet size than do non-thrombocytopenic patients with normal complete blood cell counts. A direct, linear relationship was suggested between platelet-crit and platelet count with mean platelet volume. Platelet parmeters in non-thrombocytopenic patients with normal complete blood cell counts showed no variation with respect to sex. These results do suggest that the platelet parameters may become another inexpensive and useful parameter of the routine blood cell count in thrombocytopenic patients.