각종 암환자의 말초혈액내 임파구아형 분포

Abstract

Peripheral blood from 162 patients with cancers of cervics, lung, esophagus, liver, stomach and colon, of whom 11 were metastatic, in compare with 44 normal control, was examined the lymphocyte subpopulations by immunobead method using Quantigen assay kit(Bio-rad, U. S. A.). In normal control, the proportions of T. B, null, T4 and T8 cells(%T, %B, %Null, %T4 and %T8) in peripheral blood lymphocytes were 78.9±3.3(%), 10.3±2.5(%), 10.8±3.2(%), 44.0±5.0(%) and 35.6±5.0(%), respectively, and the T4/T8 ratios were 1.28±0.32. Then, we decided our laboratorie's own normal reference values (mean±2SD) of peripheral blood lymphocyte subpopulations as following: %T as 72.3-85.5. %B as 5.3-15.3, %Null as 4.4-154, %T4 as 35.0-54.0, %T8 as 25.6-45.6, and T4/T8 ratio as 0.64-1.92. Absolute counts(/㎣) of lymphocyte, T, B, T4 and T8 cells, and %T were increased in all cancer groups. %B was increased only in cervical cancer group. %Null and alsolute counts of null cells were significantly decreased in all cancer group, especially in hepatoma and metastaic cancer group. Patients with below normal reference value of %Null were 25.5-80.0% in each cancer group and 54.5% in metastatic cancer group, but absent in control group. The increase of T4/T8 ratio and %T4 and the decrease of %T8 was significant in cervical cancer group, and the tendecy of which was noted in esophageal cancer group. Patients with below normal reference value of T4/T8 ratio were 8.3-20.0% in each cancer group, but absent in metastatic cancer and control group. Patients with below nermal reference value of %T3 were 5.9-23.9% in each cancer group and 2.3% in control group, but absent in metastatic cancer. Patients with below normal reference value of %T8 were 8.8-20.0% in each cancer group and 2.3% in control group, but absent in metastatic cancer group.