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급성거핵아구성 백혈병으로 진행된 만성 골수성 백혈병

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Affiliated Author(s)
송홍석권기영전동석박상균
Alternative Author(s)
Song, Hong SukKwon, Ki YoungJeon, Dong SeokPark, Sang Kyoon
Journal Title
Keimyung Medical Journal
Issued Date
1992
Keyword
Chronic myelogenous leukemiaMegakaryoblastic crisis
Abstract
Blast crisis is the common terminal event in chronic myelogenous leukemia (CML). In the majority of cases, the predominant immature cells in the blood and bone marrow are either of myeloid or lymphoid origin. Less frequently transformations involve the erythroid or megakaryocytic cell lines.
We experienced a case of 37-year-old man with Ph' -negative CML who developed a blastic transformation in which the predominant cell type was megakaryoblasts. He diagnosed as CML 8 months ago, thereafter he received irregular treatment only. When admission, he complained nasal bleeding and general weakness, and diagnosed under impression of blast crisis by morphologic and cytochemical study. After multiple chemotherapy, blast crisis was improved, but not resolved, and the blast crisis developed again 2 months later after admssion. At that time, seventy-nine percent megakaryoblasts were present at perpheral blood and we used immunoperoxidase stain for platelet specific antibody (Glycoprotein Ⅲa).
The stain was positive, and we could confirm acute megakaryoblastic crisis of CML.
Alternative Title
A Case of Megakaryoblastic Transformation of Chronic Myelogenous Leukemia
Department
Dept. of Internal Medicine (내과학)
Dept. of Laboratory Medicine (진단검사의학)
Dept. of Surgery (외과학)
Publisher
Keimyung University School of Medicine
Citation
손수호 et al. (1992). 급성거핵아구성 백혈병으로 진행된 만성 골수성 백혈병. Keimyung Medical Journal, 11(2), 321–329.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/14750
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 1992
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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