각화극세포종과 편평상피세포암에서의 p53단백 표현

Abstract

Mutations in the p53 gene are the most frequent genetic alterations found in human cancers to date. The tumor suppressor gene p53, located on the short arm of chromosome 17, encodes for a nuclear protein which regulates cell proliferation by inhibiting cells entering S-phase. We studied mutant p53 oncoprotein expression, using DO7 monoclonal antibody immunohistochemically, in 12 keratoacanthomas(KAs) and 11 well-, 8 moderately and, 2 poorly differentiated squamous cell carcinomas(SCCs) of the skin. p53 immunoractivity was observed in 67%(8 of 12) of KAs and 62%(13/21) SCCs were developed on ultraviolet-light exposure area. We compared staining pattern of p53 protein in the lesions of KAs and SCCs but do not find clear-cut distinction between the two lesions. However accumulation of p53 protein may play a role in the tumorigenesis of KAs and SCCs.