지질 과산화와 혈청 콜레스테롤과의 관계

Abstract

In order to study the relationship between lipid peroxidation and serum cholesterol, malondialdehyde(MDA) which is a product of free radicals mediated lipid peroxidation, serum cholesterol and high density lipopro- tein(HDL)-cholesterol were studied in 95 healthy male workers There was no significant age related increase in the MDA but an increase of up to age 40-49 was followed by a significant declme(p<0.05). The current smokers had significantly increased MDA levels compared with non-smokers(p(0.05). The weak positive correlation between cholesterol and MDA was found m current smo- kers(r=033, p<0.05). The effect of cholesterol on non-smokers and current smokers revealed that cholesterol had different effects on the MDA result from these two groups. The MDA levels of current smokers increased more rapidly in the presence of cholesterol than with non-smokers This study of normal male subjects describes a cholesterol related increase in malondialdehyde levels, the rate of which is influenced by smoking status and smoking may be one of the factors that play a role in the lipid peroxidation