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간질 발작시에 나타나는 조기유전자 발현의 변화

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Author(s)
박창교김수경
Keimyung Author(s)
Kim, Soo Kyung
Department
Dept. of Pharmacology (약리학)
Institute for Medical Science (의과학 연구소)
Journal Title
Keimyung Medical Journal
Issued Date
1996
Volume
15
Issue
3
Keyword
C-fosC-mycConvulsants
Abstract
Cellular immediate early gene expressions have been demonstrated to be modulated in response to a variety of seizure-inducing stimuli. In this study, two immediate early genes, c-fos and c-myc were investigated in response to the convulsants such as kainic acid(KA, 10mg/kg, ip). pentylenetetrazole(PTZ, 40mg/kg, ip), and N-methy1-D-aspartate(NMEA, 60mg/kg, ip) in three regions of rat brain : cerebral cortex, striatum, and brain stem. The KA and PTZ treatment slightly increased the transcription of c-fos in cerebral cortex, striatum, and brain stem. The MK-801 or baclofen pretreatment did not block the elevated expression of c-fos by KA and PTZ treatment. The NMDA treatment showed a reversal response of KA and PTZ treatment. The c-myc expression did not show a significant change in each of convulsant treatment groups and MK-801 or baclofen pretreatment did not exhibit considerable differenes.
Therefore, c-fos could be one of the first seizure-related genes expressed in a cascade of events underlying different post-translational products, which result in diverse functional consequences depending on the brain sites.
Alternative Title
Changes of
Immediate Early Gene Induction in the Drug-Induced Seizure Models
Keimyung Author(s)(Kor)
김수경
Publisher
Keimyung University School of Medicine
Citation
박창교 and 김수경. (1996). 간질 발작시에 나타나는 조기유전자 발현의 변화. Keimyung Medical Journal, 15(3), 224–230.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/14981
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 1996
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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