호지킨씨 림프종 환자에서 발생한 Disseminated Herpes Zoster 1례

Abstract

Herpes zoster is acute viral infection characterized by vesicular skin lesions which are usually distributed over several unilateral adjacent sensory dermatomes. In about 2% to 5% cases of zoster, hematogenous dissemination of virus apparently occurs. Among the associated malignancies, hematologic malignancy including Hodgkin's lymphoma, acute lymphocytic leukemia, and immunocompromised patient were frequently associated. We described the clinical manifestation of disseminated herpes zoster in patient with Hodgkin's lymphoma. A 15-years-old male patient was presented with painful grouped visicles on an erythematous base on left temporal head, right back, and right forearm. Tzanck smear revealed multinucleated giant cells, and histopathologic findings were consistent with herpetic infection. Moreover, Herpes Zoster Virus specific 220 KDDNA fragment was detected in PCR performed with vesicular fluid. Herpes Zoster Virus specific 220 KDDNA fragment was detected in PCR performed with vesicular fluid. He was successfully treated by administration of acyclovir without any significant complications.