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주정 중독 흰쥐 간의 Glyoxalase Ⅱ 활성에 미치는 총담관 결찰의 영향

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Author(s)
노태연김여희
Keimyung Author(s)
Kim, You Hee
Department
Dept. of Biochemistry (생화학)
Institute for Medical Science (의과학 연구소)
Journal Title
Keimyung Medical Journal
Issued Date
1997
Volume
16
Issue
2
Keyword
Ethanol intoxicationCholestasisGlyoxalase II
Abstract
To understand the biochemical background of alcohol hazards in hepatobiliary disease, the activities of the rat liver cytosolic and mitochondrial glyoxalase-Ⅱ(GLO-Ⅱ) were measured in cholestasis induced by common bile duct (CBD) ligation after chronic ethanol intoxication, and in cholestasis before acute ethanol intoxication.
GLO-Ⅱ activities in the rat's liver cytosol and mitochondria showed more decrease when CBD was ligated after chronic ethanol intoxication than that in the CBD ligation alone.
On the other hand, when CBD was ligated after chronic ethanol intoxication, the value of Vmax of the liver cytosolic and mitochondrial GLO-Ⅱ decreased significantly than that in the CBD was ligated alone. However, the values of Km of the liver cytosolic and mitochondrial GLO-Ⅱ did not change in the all experimental groups.
Viewed from above results, when chronic ethanol intoxication is combined with cholestasis, GLO-Ⅱ in the liver seems to be decreased its activity than that in cholestasis, and the cause of the decrease is thought to be decreased biosynthesis. Accordingly, this result will be the datum supporting that alcoholic drink to be enzymologically harmful in hepatobiliary disease.
Alternative Title
Effect of Common
Bile Duct Ligation on Glyoxalase II Activity in Ethanol Intoxicated Rat Liver
Keimyung Author(s)(Kor)
김여희
Publisher
Keimyung University School of Medicine
Citation
노태연 and 김여희. (1997). 주정 중독 흰쥐 간의 Glyoxalase Ⅱ 활성에 미치는 총담관 결찰의 영향. Keimyung Medical Journal, 16(2), 205–215.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15023
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 1997
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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