Alzheimer병의 신경병리학적 소견과 분자생물학적 연구동향

Abstract

Alzheimer's disease(AD) is the commonest form degenerative diseases of the cerebral cortex. The neuropathologically diagnostic criteria of AD are focused on the distrubution and numbers of senile plaques and neurofibrillary tangles. Its pathogenesis is not fully elucidated until now. It is clear that the amyloidogenesis and its pathogenic activity are presently the dominant hypotheses concerning the AD development. However, they are not enough in understanding the diffuse neuronal degeneration such as neurofibrillary tangles, synaptic disconnection and neuronal loss which are related to the clinial dementia syndrome.