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흰쥐 담즙울체간에서의 Glucose-6-Phosphate Isomerase 및 Fructose-1, 6-Bisphosphate Aldolase의 활성도

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Affiliated Author(s)
김여희
Alternative Author(s)
Kim, You Hee
Journal Title
Keimyung Medical Journal
Issued Date
1997
Keyword
CholestasisFructoseᅵ16-bisphospbate aldolaseQucoseᅳ6-phosphate isomerase
Abstract
This study was made to know the changes of glucose-6-phosphate isomerase (GPI) and fructose-1, 6-bisphosphate aldolase (ALS) activities in cholestatic rat livers.
GPI and ALS activities were determined in cytosolic, mitochondrial, and microsomal preparations isolater from cholestatic rat liver, and in the rat serum after common bile duct ligation for a period of forty two days.
The activities of mitochondrial and microsomal GPI in cholestatic rat liver showed a significant increase from the second day to the forty second day, and from the first day to the twenty eighth day, respectively, after the ligation. However, the cytosolic GPI activity in cholestatic liver showed a significant decrease from the twelfth hour to the second day after the ligation.
The activities of both mitochondrial and microsomal ALS in cholestatic rat liver showed a significant increase from the second day to the third day after the ligation. However, cytosolic ALS in cholestatic liver was decreased slightly from the first day to the forty second day after the ligation.
On the other hand, the activities of GPI and ALS in rat serum showed a significant increase from the twelfth hour to the seventh day, and from the first day to the forty second day, respectively, after the ligation.
These results, therefore, suggest that the biosynthesis of liver particulate-bound GPI and ALS are induced in response to cholestasis. And the elevations of both serum GPI and ALS activities seem to be leak of the enzymes into the blood from cholestatic liver
Alternative Title
Activities of Glucose-6-Phosphate Isomerase and Fructose-1, 6-Bisphosphate Aldolase in Cholestatic Rat Liver after Common Bile Duct Ligation
Department
Dept. of Biochemistry (생화학)
Institute for Medical Science (의과학 연구소)
Publisher
Keimyung University School of Medicine
Citation
최수련 and 김여희. (1997). 흰쥐 담즙울체간에서의 Glucose-6-Phosphate Isomerase 및 Fructose-1, 6-Bisphosphate Aldolase의 활성도. Keimyung Medical Journal, 16(4), 485–496.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15054
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 1997
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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