계명대학교 의학도서관 Repository

베체트병환자에서 회상항원에 대한 피부 지연과민반응의 연구

Metadata Downloads
Author(s)
김병천송준영이규석
Keimyung Author(s)
Kim, Byung ChunLee, Kyu SukSong, Joon Young
Department
Dept. of Dermatology (피부과학)
Institute for Medical Science (의과학 연구소)
Journal Title
Keimyung Medical Journal
Issued Date
1998
Volume
17
Issue
1
Keyword
Behcet's disease
Abstract
To assess cell-mediated immunity of patients with Behcet's disease, many studies have been performed by in vitro method. However, there is a little known about cell-mediated immunity of patients with Bechcet's disease by in vivo method. Thus, we investigated delayed cutaneous hypersensitivity using Multitest CMI, which is a disposable applicator preloaded with 7 recall antigens, in 82 cases including 62 cases of Behect's disease and 20 cases of control, Sixty two patients with Behcet's disease were classified into 3 types : complete, incomplete and suspected type according to the revised Shimizu method.
The results were obtained as follows:
1) Sum of average diameter of positive antigens was 6.71±1.10 mm in complete type of Behcet's disease, 12.59±3.48 mm in incomplete type 7.0±2.0 mm in suspected type, 11.13±3.36 in total of Behcet's disease and 20.38±6.06 mm in control. There was statistically significant difference between Behcet's disease and control (p<0.05).
2) Number of positive antigen was 1.7±0.51 in complete type, 2.29±0.89 in incomplete type, 3.0±1.0 in suspected type, 3.32±0.78 in total of Behcet's disease and 4.01±1.51 in control. There was statistically significant difference between Behcet's disease and control (p<0.05).
3) The rate of hyponergy in Behcet's disease and control was 32.2% and 0%, respectively. The rate of energy in Behcet's disease and control was 4.8% and 0%, respectively.
4) Antigens acquired strongest reaction were all tuberculin in Behcet's disease (positivity; 81%) and control (95%). Antigens acquired weakest reaction were all tetanus in Behcet's disease (7%) and control (10%). Unexpectedly, the positivity of streptococcus suggested as one of etiologic agents in Behcet's disease was 10% in Bechet's disease and 56% in control.
Taken altogether, our study revealed cell-mediated immunity of Behcet's disease measured by multitest CMI was decreased and it is suggested that decreased cell-mediated immunity in Behcet's disease is related, at least in part, to the disease severity and involved in the pathogenesis of this disease.
Alternative Title
Study of Delayed Cutaneous Hypersensitivity Reactions to the Recall Antigens in Patients with Behcet's Disease
Keimyung Author(s)(Kor)
김병천
이규석
송준영
Publisher
Keimyung University School of Medicine
Citation
김병천 et al. (1998). 베체트병환자에서 회상항원에 대한 피부 지연과민반응의 연구. Keimyung Medical Journal, 17(1), 61–71.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15065
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 1998
1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.