계명대학교 의학도서관 Repository

전립선암의 치료에서 간헐적 안드로젠 차단요법의 초기경험

Metadata Downloads
Author(s)
이병태박철희김천일
Keimyung Author(s)
Park, Choal HeeKim, Chun Il
Department
Dept. of Urology (비뇨의학)
Journal Title
Keimyung Medical Journal
Issued Date
1998
Volume
17
Issue
2
Keyword
Prostate cancerIntermittent androgen suppression
Abstract
The increasing interest in exploring the use of intermittent androgen deprivation in prostate cancer has prompted a retrospective review of patients who elected to stop treatment.
Observations were made on 10 patients. Treatment was initiated with goserelin acetate with flutamide or goserelin acetate alone and continued until a serum PSA nadir was observed. medication was then withheld until the serum PSA increased to a median value between 10 and 20 ng/ml.
The first two treatment cycles lasted 12.5 and 14 months, with mean time off therapy of 5.1 and 7 months and an overall mean percentage time off therapy of 41% and 50%, respectively. The mean time to achieve a nadir level of serum PSA was 5.7 months in cycle 1 and 4.3 months in cycle 2. The off treatment in both cycles was associated with an improvement in sense of well-being and the recovery of libido.
Prostate cancer is amenable to control by intermittent androgen suppression. This approach affords an improved quality of life when the patient is off therapy. It also results in reduced toxicity and cost of treatment. Whether tumor progression is affected in beneficial or adverse way remains to be studied in a randomized, prospective study.
Alternative Title
Early Experience of
Intermittent Androgen Suppression in the Treatment of Prostate Cancer
Keimyung Author(s)(Kor)
박철희
김천일
Publisher
Keimyung University School of Medicine
Citation
이병태 et al. (1998). 전립선암의 치료에서 간헐적 안드로젠 차단요법의 초기경험. Keimyung Medical Journal, 17(2), 186–191.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15078
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 1998
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.