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반코마이신 정주투여후 발생한 위막성 대장염 1례

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Affiliated Author(s)
류성열박근용이인규
Alternative Author(s)
Ryu, Seong YeolPark, Keun YongLee, In Kyu
Journal Title
Keimyung Medical Journal
Issued Date
1998
Keyword
Pseudomembranous colitisIntravenous vancomycin
Abstract
Diarrhea is a common complication of antibiotics usage. The diarrhea ascribed to antibiotics usually consist of loose or watery stools, sometimes containing mucus but rarely gross evident blood. Almost every antibiotics has been implicated. Although the pathogenesis of antibiotics-associated diarrhea is not confirmed, recent studies have shown that a toxin of Clostridium difficile is implicated as a cause of it. Diagnosis is made by detecting toxin in the stool or by positive stool culture for C. difficile. Treatment is either directed at binding the toxin with anion exchange resins such as cholestyramine in mile case, or at eradicating the C. difficile organism with oral vancomycin, metronidazole for more severe cases.
We have recently experienced one patient who developed diarrhea, abdomminal pain after having received prolonged vancomycin injection. Sigmoidoscopic finding revealed typical cream-colored plaque lesions (pseudomembrane) on a red friable edematous mucosa. Light microscopic finding of the rectal mucosa showed a volcano-like appearance. The symptom improved after treatment with oral vancomycin and metronidazole.
So, we report one case of pseudomembranous colitis secondary to the use of parenteral vancomycin.
Alternative Title
Pseudomembranous
Colitis Secondary to Intravenous

Vancomycin
Department
Dept. of Internal Medicine (내과학)
Institute for Medical Science (의과학 연구소)
Publisher
Keimyung University School of Medicine
Citation
박진용 et al. (1998). 반코마이신 정주투여후 발생한 위막성 대장염 1례. Keimyung Medical Journal, 17(3), 421–428.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15102
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 1998
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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