고해상력 CT를 이용한 실험견 이식폐의 변화 관찰

Abstract

We analyzed CT findings of reperfusion injury, acute rejection, infection and infarction of the left single allotransplated lung of dogs, and the CT findings were compared with the histological findings obtained by the lung biopsy and autopsy. Twenty two adult mongrel dogs were divided into donor and recipient groups. Donor lungs were flushed with LPDG(low potassium dextran glucose) solution(n=4) or modified Euro-Collins solution (n=7) and preserved over 20 hours with 10℃(1 case preserved for 4 hours). After transplantation, chest X-ray and sequential CT were performed with concomitant hemodynamic study and arterial blood gas analysis on immediate postoperative period, postoperative 3rd day and postoperative 7th day. Two of eleven transplanted lungs had acute rejection which was represented as mixed consolidation and ground glass opacity on CT in both cases. The similar CT findings were also noted in three of six transplanted lungs with pneumonia. Cystic change was demonstrated in the consolidation on 7th day follow-up CT in one of two cases with infarction. Pneumopericardium was noted in case with bronchopleural fistula. We concluded that CT was useful for early detection of various complications in the transplanted lung.