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한번의 간질발작 후 혈청 Neuron-Specific Enolase 농도 변화

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Author(s)
최승호박영춘이장준임정근김지언이상도
Keimyung Author(s)
Kim, Ji EunLim, Jeong GeunYi, Sang DoPark, Young Chun
Department
Dept. of Neurology (신경과학)
Journal Title
Keimyung Medical Journal
Issued Date
1999
Volume
18
Issue
4
Keyword
Neuron specific enolaseBrain damageSeizure
Abstract
An increase in neuron-specific enolase (NSE) levels in serum and CSF has been shown to be an useful marker of brain damage after stroke, global ischemia, and coma. We report the changes of serum NSE levels after seizure attacks in epileptic patients compared with the levels in normal controls and epileptic patients without seizure attack at least 7 days (epileptic controls). Twenty-four seizures were included in this study. Blood was drawn within 1 hour, at 12 hour, 24 hour, and 48 hour after seizure attack. Serum NSE levels were measured with radioimmunoassay. The mean NSE levels for normal controls and epileptic controls were 6.94 ng/ml and 7.46 ng/ml, respectively. There were significant increase in level of serum NSE measured within 1 hour after seizure attack in epileptics compared with the level in normal controls (15.10ng/ml versus 6.94ng/ml, p<0.05) and epileptic controls (15.10ng/ml versus 7.46ng/ml, p<0.05). Serum NSE measured at 12 hours after seizure also increased compared with normal controls (12.32ng/ml versus 6.94ng/ml, p<0.05) and epileptic controls (12.43ng/ml versus 7.46ng/ml, p<0.05). Between normal controls and epileptic controls, there were no significant difference in serum NSE levels. We conclude that serum NSE level was elevated in epileptic patients who had seizure attack within 12 hours. Serum NSE levels can be useful marker for seizure within 12 hours after onser. The elevated serum NSE level after single seizure attack may suggest that the brain was injured in single seizure.
Alternative Title
Serum Neuron-
Specific Enolase Concentration After Single Seizure
Keimyung Author(s)(Kor)
김지언
임정근
이상도
박영춘
Publisher
Keimyung University School of Medicine
Citation
최승호 et al. (1999). 한번의 간질발작 후 혈청 Neuron-Specific Enolase 농도 변화. Keimyung Medical Journal, 18(4), 501–508.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15174
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 1999
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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